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Association of alpha fibrinogen -58G/A genetic polymorphisms with acute coronary syndrome in type 2 diabetes mellitus |
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| รหัสดีโอไอ | |
| Creator | Chananikan Makmool |
| Title | Association of alpha fibrinogen -58G/A genetic polymorphisms with acute coronary syndrome in type 2 diabetes mellitus |
| Contributor | Nantarat Komanasin, Burabha Pussadhamma, Wit Lueangwattananon |
| Publisher | Faculty of Associated Medical Sciences, Khon Kaen University, Thailand |
| Publication Year | 2563 |
| Journal Title | Archives of Allied Health Sciences |
| Journal Vol. | 32 |
| Journal No. | 3 |
| Page no. | 50-57 |
| Keyword | Fibrinogen, polymorphism, diabetes mellitus, acute coronary syndrome |
| URL Website | https://he01.tci-thaijo.org/index.php/ams/about |
| Website title | Archives of Allied Health Sciences (Arch AHS) |
| ISSN | 2730-1990 |
| Abstract | Fibrinogen is one of the inflammatory markers and plays a crucial role in pathophysiological process of cardiovascular diseases (CVD). High levels of fibrinogen are associated with atherosclerosis progression and CVD complication in type 2 diabetes mellitus (DM). Furthermore, fibrinogen genetic polymorphisms are one of the important factors affecting their levels. Therefore, this study aimed to evaluate the associations of FGA -58G/A polymorphism with clinical manifestations of coronary artery disease (CAD) in type 2 DM. A case-control study included 123 documented DM patients presenting with either acute coronary syndrome (ACS) or stable CAD and 86 control individuals without DM and presenting none or less than 50% stenosis of coronary artery. All subjects were genotyped for the FGA -58G/A polymorphism by using polymerase chain reaction-restriction fragment length polymorphism technique. The results showed that AA genotype and A allele of the FGA -58G/A polymorphism were independently associated with DM [adjusted OR (95% CI) = 3.3 (1.2, 8.9) and 3.3 (1.6, 6.6), respectively]. Moreover, the AA genotype and A allele were also significantly associated with ACS in diabetic patients [adjusted OR (95% CI) = 3.9 (1.3, 11.7) and 2.0 (1.2, 3.5), respectively], while the association with stable CAD was not observed. In conclusion, the results of this study may indicate the association of the FGA -58G/A polymorphism with the atherosclerotic progression which may in turn leads to the severe clinical manifestation of CAD in DM. |
