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Development and evaluation of curcumin nano emulsion in moisturizer for antiaging |
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| รหัสดีโอไอ | |
| Creator | Venkatesh D. Puttegowda |
| Title | Development and evaluation of curcumin nano emulsion in moisturizer for antiaging |
| Contributor | Roopa Karki |
| Publisher | Asia-Pacific Journal of Science and Technology |
| Publication Year | 2567 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 29 |
| Journal No. | 3 |
| Page no. | 15 (11 pages) |
| Keyword | Curcumin, Ternary phase diagram, Thermodynamic stability, Olive oil, Nano moisturizer |
| URL Website | https://so01.tci-thaijo.org/index.php/APST/ |
| Website title | https://so01.tci-thaijo.org/index.php/APST/article/view/265158 |
| ISSN | 2539-6293 |
| Abstract | In this study, an attempt was made to prepare a curcumin nano moisturizer. Curcumin is a powerful antioxidant that neutralizes free radicals and reactive oxygen species. (ROS). Various formulations were prepared by utilizing a pseudo-ternary phase diagram and an appropriate surfactant and co-surfactant mixture (Smix), with olive oil serving as the oil phase. Curcumin and excipients were found to be compatible in FTIR investigations, and droplet dispersion analysis was performed on all formulations. The formulation F3 was found to be optimal, with particle size and zeta potential of mean n=3, 506.30.43 nm, and -31.10.04 mV, respectively. It was characterized and evaluated for viscosity, spreadability, pH, thermodynamic stability studies, robustness to dilution ratio, percent transmittance, drug diffusion studies, and free radical scavenging assay by using DPPH, F3 formulation inhibited 88% of free radicals, which was more than the positive control, ascorbic acid, and it suppressed ROS generation. Short-term stability studies on optimized curcumin nano moisturizer show that it can be stored in a well-closed wide-mouth container for two months at 40±2°C and 75% RH. As a result, the prepared nano moisturizer showed to be a potential anti-aging cosmeceutical candidate. |
