|
The in vivo preventive effect of some medicinal plant extracts on the development of hydatid cyst infection |
|---|---|
| รหัสดีโอไอ | |
| Creator | Yaseen T. Al Qaisi |
| Title | The in vivo preventive effect of some medicinal plant extracts on the development of hydatid cyst infection |
| Contributor | Khaled M. Khleifat, Sawsan A. Oran, Ibrahim I. Alfarrayeh, Ahmad Z. Alsarayreh,Mohammad A. Abu-lubad, Bushra K. Al-Tarawneh |
| Publisher | Asia-Pacific Journal of Science and Technology |
| Publication Year | 2566 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 28 |
| Journal No. | 3 |
| Page no. | 10 |
| Keyword | E. granulosus, Hydatid cysts, Medicinal plants, Secondary infection |
| URL Website | https://www.tci-thaijo.org/index.php/APST |
| Website title | https://so01.tci-thaijo.org/index.php/APST/article/view/255343 |
| ISSN | 2539-6293 |
| Abstract | This study aimed to explore the preventive effect of the methanolic extracts of the seeds of Citrullus colocynthis, and the aerial parts of Ruta graveolens and Peganum harmala on the development of secondary infection of Echinococcus granulosus in vivo. The viable protoscolices were subjected to 40 mg/mL of methanolic extracts of the three plants for 4 hours of exposure times in vitro, then injected into male Albino-Wistar rats for 8 months. Compared to the negative control group, R. graveolens methanolic extract showed high significant (p< 0.05) protoscolicidal and preventive effects on the secondary hydatid cysts growth similar to that recorded in albendazole (ABZ) drug. However, P. harmala and C. colocynthis methanolic extracts showed low preventive effects on the secondary hydatid cysts' growth. The preventive effects were represented by the reduction in the infection rate, cysts number, size, and weight. In addition to the high significant changes (p< 0.05) in values of hematological and biochemical parameters, elevation of gamma interferon (IFN-?) levels and decline of interleukin-10 (IL-10) and IL-4 cytokines compared to the negative control group. |
