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Harnessing Chnoospora minima (Hering) Papenfuss (Scytosiphonaceae, Ochrophyta) for pharmaceutical application: Antioxidant, antibacterial, tyrosinase and elastase inhibition properties |
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| รหัสดีโอไอ | |
| Creator | Eldrin DLR. Arguelles |
| Title | Harnessing Chnoospora minima (Hering) Papenfuss (Scytosiphonaceae, Ochrophyta) for pharmaceutical application: Antioxidant, antibacterial, tyrosinase and elastase inhibition properties |
| Contributor | Eldrin DLR. Arguelles |
| Publisher | Asia-Pacific Journal of Science and Technology |
| Publication Year | 2566 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 28 |
| Journal No. | 3 |
| Page no. | 11 |
| Keyword | Algae, Bioactive compound, Biological activity, Chnoospora minima,Marine, Philippines, Seaweed, Tropical |
| URL Website | https://www.tci-thaijo.org/index.php/APST |
| Website title | https://so01.tci-thaijo.org/index.php/APST/article/view/267715 |
| ISSN | 2539-6293 |
| Abstract | Marine algae are untapped alternative sources of bioactive substances with important biological activities that can be harness for pharmaceutical application. The proximate composition and some important biological properties of brown macroalga, Chnoospora minima (Hering) Papenfuss were studied. Results showed that proximate composition of C. minima contain high carbohydrate (33.09 ? 0.14%), protein (25.89 ? 0.01%) and ash (18.79 ? 0.02%) content. The seaweed contain a total phenolic content of 9.90 ? 0.08 mg gallic acid equivalents (GAE)/g. Antioxidant efficiency of C. minima were observed to have potent 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS+) scavenging activity and good copper reduction capacity with IC50 value of 129 ?g/mL and 28.59 ?g/mL, respectively. In vitro evaluation of the tyrosinase and elastase inhibition properties showed that C. minima extract has potent enzyme inhibitory activities with half maximal inhibitory concentration (IC50) values of 36.0 ?g/mL and 56.0 ?g/mL, respectively more effective than kojic acid and tocopherol. The algal extract showed effective antibacterial activities against Staphylococcus aureus minimum inhibitory concentration ((MIC) = 125 ?g/mL), Listeria monocytogenes (MIC = 250 ?g/mL), and Aeromonas hydrophila (MIC = 250 ?g/mL). The study is the first documented report in the Philippines describing the noteworthy biological activities of C. minima that can be harnessed as source of novel bioactive compounds for human use. |
