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Biological activities of crude exopolysaccharidesproduced by the bacteria isolated from plasmodia of slime molds |
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| รหัสดีโอไอ | |
| Creator | Hanh TM Tran |
| Title | Biological activities of crude exopolysaccharidesproduced by the bacteria isolated from plasmodia of slime molds |
| Contributor | Tuyen T. H. Do, Tram T. H. Huynh, Ngoc N. Truong |
| Publisher | Asia-Pacific Journal of Science and Technology |
| Publication Year | 2564 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 26 |
| Journal No. | 3 |
| Page no. | 7 |
| Keyword | Antiproliferative activity, Symbiotic bacteria, Exopolysaccharides, Fuligo septica, Physarella oblonga |
| URL Website | https://www.tci-thaijo.org/index.php/APST |
| Website title | https://so01.tci-thaijo.org/index.php/APST/article/view/249396 |
| ISSN | 2539-6293 |
| Abstract | Slime molds are an unusual group of fungus-like protozoans, and one of their trophic stages (the plasmodium) is often found to be associated with certain unique bacteria not normally found in their regular habitats. Four different strains of bacteria were previously isolated from plasmodia (generated from fruiting bodies under laboratory conditions) of the slime molds Physarella oblonga and Fuligo septica. The bacteria were genetically classified as members of the genera Enterobacter, Stenotrophomonas, and Alcaligenes. The crude exopolysaccharides (EPSs) from the four species of bacteria were isolated and evaluated for their antioxidant and anti-proliferative activities. Mild in vitro antioxidant activities were recorded for all the samples. However, at a concentration of 1 mg/mL, the crude EPSs from Enterobacter sp. (C1) and Stenotrophomonas sp. 1 (C2) showed significant anti-proliferative activities against HeLa cervical cancer cells, with the antiproliferative rates of 41.31% and 36.19%, respectively. Remarkably, they displayed negligible antiproliferative activities toward bovine aortic endothelial cells. These data suggested that further investigations, including purification of the EPS samples and evaluation of their cytotoxicity against HeLa cells, should be carried out. |
