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Hepatitis C Virus Associations with Non Hodgkins Lymphoma: Insights on In ammation/Angiogenesis and CD Markers |
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| รหัสดีโอไอ | |
| Creator | 1. Eman A El-Maadawy 2. Roba M Talaat; Rawia F Sadek; Sherif M El-Sherbini; Naser Abdel-Bary; Amal A Abdel-Aziz |
| Title | Hepatitis C Virus Associations with Non Hodgkins Lymphoma: Insights on In ammation/Angiogenesis and CD Markers |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 9 |
| Page no. | 4415-4420 |
| Keyword | NHL; HCV; in ammation; CD; angiogenesis |
| Abstract | We aimed to investigate any association between hepatitis C virus (HCV) infection and non-Hodgkinีs lymphoma (NHL) in the view of cytokines that control in ammation/angiogenesis and their correlation with certain CD markers. NHL patients with or without HCV infection were studied. CD5, CD30, CD3, CD20 and CD45 were immunohistochemically evaluated. Plasma levels of vascular endothelial and platelet derived growth factors (VEGF, and PDGF), tumor necrosis factor (TNF-_), transforming growth factor (TGF-_), interleukin-6 (IL-6), IL-8, IL-4, IL-12 and interferon gamma (IFN-_) were detected by enzyme-linked immunosorbent assay (ELISA). HCV+ve NHL patients showed a signi cant reduction in VEGF, PDGF, IFN-_, CD5 and CD45 and a signi cant increase in IL-12 and IL-8. In conclusion, there was a signi cant change in cytokine secretion and expression of CD markers in HCV+ve NHL patients. Based on our results, HCV infection in NHL patients requires more in-depth investigations to explore any role in lymphoma progression. |
