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Potential Risk Factors for Breast Cancer in Pakistani Women |
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| รหัสดีโอไอ | |
| Creator | 1. Raisa Bano 2. Muhammad Ismail; Aamer Nadeem; Mohammad Haroon Khan; Hamid Rashid |
| Title | Potential Risk Factors for Breast Cancer in Pakistani Women |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 9 |
| Page no. | 4307-4312 |
| Keyword | Breast cancer; case-control study; risk factors; socio-demographic; reproductive; life style; Pakistan |
| Abstract | Background: Breast cancer is the most common female malignancy worldwide and its incidence is on the rise in Pakistan. The aim of this case-control study was to quantify the association of various risk factors with breast cancer risk among Pakistani women. Materials and Methods: A total of 2,246 women were studied, including 1,238 women with histologically con rmed breast cancer patients and age matched control subjects (N=1008) without breast cancer and other chronic diseases. Subjects were interviewed using a speci cally designed questionnaire. Unconditional logistic regression was applied. Subsequent disease-speci c mortality was also measured. Results: In this study, majority of the breast cancer patients (69.59%) were in age ranges of 40s and 50s. BMI greater than 25kg/m2 (OR=1.57; 95%CI, 1.26-1.90 and OR=1.60; 95%CI, 1.26-2.03), marital status of unmarried (OR=2.03; 95%CI, 1.69-2.44), lack of breast feeding, smoking (current or ever), lack of physical activity and post-menopausal status were found to have signi cant positive associations with breast cancer. It was also observed that increased parity reduced the disease risk. A larger number of cases (58.1%) had their right breast affected while 22.8% had other complications as well. Conclusions: This exploratory analysis indicated a number of risk factors to be associated with increased risk of breast cancer. It was also observed that mean age at diagnosis is a decade earlier than in western countries. It is hoped that our ndings will facilitate establishment of adequate evidence-based awareness and preventive measures for Pakistani women. |
