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Association between Pax8-PPAR_1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis |
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| รหัสดีโอไอ | |
| Creator | 1. Hang-Yu Li 2. Zhi-Hao Xie; Cong-Hui Xu; Mei-Ling Pu; Zi-Yan Chen; Miao Yu; Heng-Shu Wang; Chen-Ming Zhou; Chao-Yu Pu; Wei Liu |
| Title | Association between Pax8-PPAR_1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 9 |
| Page no. | 4247-4250 |
| Keyword | Follicular thyroid cancer; Pax8-PPAR 1 rearrangement; meta-analysis |
| Abstract | Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-PPAR_1) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- PPAr_1 rearrangement. In order to have a better understanding of the association between Pax8-PPAR_1 rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a xed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-PPAR_1 rearrangement was signi cantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-PPAR_1 rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR. Conclusions: The nal results demonstrated that Pax8-PPAR_1 rearrangement has signi cant association with follicular thyroid cancer. |
