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Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population |
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| รหัสดีโอไอ | |
| Creator | 1. Sukumaran Anil 2. PB Gopikrishnan; Ashik Bin Basheer; BG Vidyullatha; Yahya A Alogaibi; Elna P Chalisserry; Fawad Javed; MHN Dalati; Sajith Vellappally; Mohamed Ibrahim Hashem; Darshan Devang Divakar |
| Title | Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 8 |
| Page no. | 4107-4111 |
| Keyword | Oral squamous cell carcinoma ; poly (ADP-Ribose) polymerase 1 ; risk factor |
| Abstract | Background: Oral cancers account for approximately 2% of all cancers diagnosed each year- however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is ve to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population. Materials and Methods: In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 single nucleotide peptides (SNP๊s) rs1136410 and rs3219090 using TaqMan assays. Results: The results indicated signi cantly higher risk with PARP1 rs1136410 minor allele C" (OR=1.909- p=0.02942- CI, 1.060- 3.439). SNP rs1136410 also showed signi cantly increased risk in patients with smoking habit at C/C genotype and at minor allele C. Conclusions: The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with a greater number of samples are needed to verify these ndings. |
