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Talin-1 and Non-invasive Fibrosis Models in the Assessment of Patients with Hepatocellular Carcinoma |
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| รหัสดีโอไอ | |
| Creator | 1. Ayman Alsebaey 2. Eman Aly Ahmedy |
| Title | Talin-1 and Non-invasive Fibrosis Models in the Assessment of Patients with Hepatocellular Carcinoma |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 8 |
| Page no. | 4077-4082 |
| Keyword | Hepatocellular carcinoma ; cirrhosis ; serum talin-1 ; fibro-alpha ; brosis index ; scores ; lesion size |
| Abstract | Background: Hepatocellular carcinoma (HCC) is a dreadful complication of end stage liver disease with high morbidity and mortality. Aim: The aim is to assess the role of serum talin-1 and non-invasive brosis in patients with HCC. Materials and Methods: A total of eighty seven subjects were enrolled, 22 two healthy individuals as a control group (n=22), 22 patients in the cirrhosis group and nally 43 in the group with HCC diagnosed with positive triphasic CT abdomen criteria. Serum talin-1 and noninvasive brosis parameters were assessed in all subjects. Results: Compared to the cirrhosis group, patients with HCC had higher serum talin-1 (32.9ฑ12.6 vs. 11.1ฑ2.79 ng/ml), FIB4 (9.96ฑ15.3 vs. 2.90ฑ1.87) and bro-_ (10.9ฑ18.1 vs. 1.55ฑ0.28) but not brosis index scores (4.47ฑ0.95 vs. 4.98ฑ0.96- p=0.046). Patients with large focal lesions (_5cm) had different ALBI scores (-1.02ฑ0.63 vs. -1.72ฑ0.59- p=0.001) serum talin-1 (9.72ฑ13.81 vs. 28.6ฑ38.89 ng/ml- p=0.007) and brosis index scores (0.85 ฑ 0.99 vs. 4.20ฑ4.85- p=0.026). No statistical differences were noted between patients with and without portal vein thrombosis. For detection of HCC, serum talin-1 had 97.7% sensitivity and 100% speci city with a 17.2 ng/ml cutoff. AFP at a 13.7 ng/ml cutoff had 72.1% sensitivity and 6.3.6% speci city. The cutoff for the bro-_ score was 1.61 with 81.4% sensitivity and 77.3% speci city. Serum talin-1 (odds=1.08- C.I=1.016-1.150- p=0.014), brosis index score (odds=2.35- C.I=1.055-5.217- p=0.037) and the ALBI score (odds=6.9- C.I=1.924-24.708- p=0.003) were predictors of large focal lesions. Conclusions: Serum talin-1, AST/ALT ratio, bro-_ score are useful for the assessment of HCC patients. |
