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Clinico-Hematological Findings for Classical Hodgkin๊s Lymphoma: an Institutional Experience |
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| รหัสดีโอไอ | |
| Creator | 1. Sadia Sultan 2. Syed Mohammed Irfan; Saira Parveen; Saif Ali |
| Title | Clinico-Hematological Findings for Classical Hodgkin๊s Lymphoma: an Institutional Experience |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 8 |
| Page no. | 4009-4011 |
| Keyword | Hodgkin๊s lymphoma ; staging ; histopathology ; Pakistan |
| Abstract | Background: Classical Hodgkin๊s lymphoma (cHL) is a B-cell lymphoid neoplasm characterized by a distinctive biological behavior with potentially curable disease characteristics. It is an uncommon hematological malignancy which primarily affects younger individuals. The rationale of this study was to determine its clinico-hematological pro le along with stage strati cation in Pakistani patients. Materials and Methods: In this descriptive study, adult patients with Hodgkin๊s lymphoma were enrolled from January 2010 to December 2014. Results: Sixty two histopathologically con rmed cases of cHL were identi ed. There were 42 males and 20 females, with a male to female ratio of 2: 1. The mean age was 29.7ฑ13.8 years with the median age of 30 years. B symptoms were present in 72.5% of patients. Histopathologically, the mixed cellularity type constituted 62.9% of cases, followed by nodular sclerosis in 25.8%, lymphocyte predominant in 9.6% and lymphocyte depleted in 1.6%. Stages I and II were present in 43.5% of patients at disease presentation, with 56.4% in stages III and IV. Conclusions: Our analysis shows that clinico-pathological features of Hodgkin๊s lymphoma in Pakistan are comparable to published data. Mixed cellularity is the commonest histological variant and advanced stage at presentation are common ndings in our patients. |
