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Polysaccharide from Polygonatum Inhibits the Proliferation of Prostate Cancer-Associated Fibroblasts Cells |
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| รหัสดีโอไอ | |
| Creator | 1. Shu-Yu Han 2. Ming-Hua Hu; Guan-Yun Qi; Chao-Xiong Ma; Yuan-Yuan Wang; Fang-Li Ma; Ning Tao; Zhi-Hai Qin |
| Title | Polysaccharide from Polygonatum Inhibits the Proliferation of Prostate Cancer-Associated Fibroblasts Cells |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 8 |
| Page no. | 3829-3833 |
| Keyword | Cancer associated broblasts ; polysaccharide from polygonatum ; autophagy ; tumor ; therapy |
| Abstract | Inhibition of cancer-associated broblasts (CAFs) may improve the ef cacy of cancer therapy. Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (p<0.001) without inhibiting the growth of normal broblasts (NAFs). Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs. 3-methyl-adenine(3-MA) is an autophagy inhibitor. 3-MA was added to prostate-CAFs with polysaccharide from polygonatum to determine whether autophagy plays an important role in the restrained effect. Finally, polysaccharide from polygonatum treatment signi cantly increased the activation of Beclin-1 and LC3, key autophagy proteins. Polysaccharide from polygonatum stimulates autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate- CAFs. |
