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The role of auto anti-double stranded DNA antibodies mediated human mesangial cells microRNA-10a resulting in interleukin-8 upregulation and cells proliferation |
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| รหัสดีโอไอ | |
| Title | The role of auto anti-double stranded DNA antibodies mediated human mesangial cells microRNA-10a resulting in interleukin-8 upregulation and cells proliferation |
| Creator | Pattarin Tangtanatakul |
| Contributor | Prof. Dr. Nattiya Hirankarn, M.D., Assist. Prof. Dr. Asada Leelahavanichkul, M.D., BoonyakiatThammasate, M.D., Assoc. Prof. Alain Jaquet, Dr. RangsimaReantragoon, M.D., Trairak Pisitkun, M.D., Prof. Dr. YingyosAvihingsanon, M.D. |
| Publisher | Medical Microbiology Interdisciplinary Program |
| Publication Year | 2560 |
| Keyword | Anti-dsDNA antibodies, Mesangial cells, microRNA-10a, interleukin-8 |
| Description | In the early phase, auto antibodies (Ab) attach to chromatin structure or membrane antigens on human mesangial cell (HMC) membranes inducing complement fixation. The miR-10a is downregulated and enhances cell proliferation or apoptosis through HOXA1, KLF4,and CREB1. IL8 or CXCL8 are putative direct targets of miR-10a. The IL-8 attracts phagocytes into the kidney. HMCs interact with endothelial cells and the glomerular basement membrane, and abnormal functions of HMCs might disturb other resident kidney cell functions. The increase in HMC number might increase mesangial matrixes resulting in chromatin or apoptotic body accumulation. In summary, these processes might drive the progression of lupus nephritis (LN) disease and provide insights into LN pathogenesis. |
| Format | PICTURE |
| URL Website | https://explore.nrct.go.th/search_detail/result/4234 |
| Date and time | 2560 |
| Website title | ห้องสมุดงานวิจัยสำหรับสาธารณะ (Extraordinary SimplPublic Library of Research Result : EXPLORE) |
