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The role of nuclear factor erythroid2-related factor 2 (Nrf2)-regulated antioxidant defenses in UVA-induced matrix metalloproteinase-1 (MMP-1) in HaCaT keratinocyte cells and mouse skin: the effect of Thai Herbal Antipyretic 22 Formula (APF22) |
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| รหัสดีโอไอ | |
| Title | The role of nuclear factor erythroid2-related factor 2 (Nrf2)-regulated antioxidant defenses in UVA-induced matrix metalloproteinase-1 (MMP-1) in HaCaT keratinocyte cells and mouse skin: the effect of Thai Herbal Antipyretic 22 Formula (APF22) |
| Creator | รศ.ดร.พญ.อุไรวรรณ พานิช |
| Contributor | น.ส.อัญมณี ชัยประสงค์สุข |
| Publisher | ภาควิชาเภสัชวิทยา คณะแพทยศาสตร์ศิริราชพยาบาล |
| Publication Year | 2560 |
| Keyword | human keratinocyte HaCaT cells (HaCaT), matrix metalloproteinase-1 (MMP-1), nuclear factor E2-related factor 2 (Nrf2), Thai herbal antipyretic 22 formula (APF22), ultraviolet A (UVA) |
| Description | This study investigated the role of Nrf2 in modulation of UVA-mediated MMP-1 upregulation in human keratinocyte (HaCaT) cells and explored the anti-photoaging effects of APF22, the medicinal herbs, having abilities to activate Nrf2 on MMP-1 and collagen expressions in association with phosphorylation of MAPKs (ERK, JNK and p38), c-Fos and c-Jun in the skin of BALB/c mice irradiated with UVA. In conclusion, Nrf2 plays a photoprotective role in UVA-mediated MMP-1 upregulation. Additionally, APF22 with Nrf2 activating properties could protect against UVA-induced MMP-1 expression through MAPK/AP-1 pathway and may represent promising anti-photoaging candidates. |
| Format | PICTURE |
| URL Website | https://explore.nrct.go.th/search_detail/result/3432 |
| Date and time | 2560 |
| Website title | ห้องสมุดงานวิจัยสำหรับสาธารณะ (Extraordinary SimplPublic Library of Research Result : EXPLORE) |
