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Moringa oleifera seed oil promotes hair growth in miceand modulates the genetic expressions of factors affectinghair growth cycle in skin cell culture |
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| รหัสดีโอไอ | |
| Creator | 1. Jintana Junlatat 2. Bungorn Sripanidkulchai |
| Title | Moringa oleifera seed oil promotes hair growth in miceand modulates the genetic expressions of factors affectinghair growth cycle in skin cell culture |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 3 |
| Page no. | 817-825 |
| Keyword | moringa oil, hair growth, skin thickness, genetic expressions |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Moringa oleifera Lam. seed oil (MO) has traditionally been used for hair loss and several products are commerciallyavailable with limited scientific evidence. This study aimed to investigate the hair growth-promoting effect of MO using cellbased and animal models. MO samples were selected to test for the effects on the genetic expressions of four factors related tohair growth cycle (VEGF, TGF-ฮฒ1, 5ฮฑ-reductase I and II) by RT-PCR method. MO up-regulated the expression of VEGF geneand down-regulated the expressions of the other three genes. MO showed hair growth-promoting effects via hair growth-relatedgene expression on both keratinocytes and derma papilla cells and comparable to the effects of the minoxidil. After applicationon C57BL/6 mice, MO increased the hair growth of the mice. Histological examination of the mouse skin showed that MOincreased skin thickness, number of hair follicles and anagen-to-telogen ratio. The obtained results suggest the hair growthpromoting effect of moringa oils. |
