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Hypocholesterolemic mechanism of phenolics-enriched extract fromMoringa oleifera leaves in HepG2 cell lines |
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| รหัสดีโอไอ | |
| Creator | 1. Peera Tabboon 2. Bungorn Sripanidkulchai 3. Kittisak Sripanidkulchai |
| Title | Hypocholesterolemic mechanism of phenolics-enriched extract fromMoringa oleifera leaves in HepG2 cell lines |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2559 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 2 |
| Page no. | 155-161 |
| Keyword | Moringa oleifera,LDL receptor,hypolipidemic,HepG2 cell,HMG CoA reductase,phenolics |
| ISSN | 0125-3395 |
| Abstract | Previous studies have demonstrated the hypolipidemic activity of Moringa oleifera (MO) leaves via lowering serumlevels of cholesterol, but the mechanism of action is unknown. In this study, we demonstrated the hypocholesterolemicmechanism of a phenolics-enriched extract of Moringa oleifera leaf (PMO) in HepG2 cells. When compared to the controltreatment, PMO significantly decreased total intracellular cholesterol, inhibited the activity of HMG CoA reductase in a dosedependentmanner and enhanced LDL receptor binding activity. Moreover, PMO also significantly increased the geneticexpressions of HMG CoA reductase and LDL receptor. |
