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Correlation between Regression of Postoperative CA125 Level in Epithelial Ovarian Cancer and 3-Year Progression Free Survival |
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| รหัสดีโอไอ | |
| Creator | Manita Ruktaprajit |
| Title | Correlation between Regression of Postoperative CA125 Level in Epithelial Ovarian Cancer and 3-Year Progression Free Survival |
| Contributor | Narumon Vichiensomsakun |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2565 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 30 |
| Journal No. | 6 |
| Page no. | 385-392 |
| Keyword | regression of postoperative CA125, epithelial ovarian cancer, progression free survival |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To examine the relationship between regression of postoperative cancer antigen 125 (CA 125) level in epithelial ovarian cancer and 3-year progression free survival. Materials and Methods: A retrospective study was conducted in patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I-IV epithelial ovarian cancer treated by complete surgical staging or primary debulking surgery between 2013 and 2017 at Prapokklao Hospital, Chanthaburi, Thailand. The study focused on pre-postoperative decline of serum CA 125 level. Three-year progression free survival analyses were conducted by the Kaplan-Meier method, log-rank test and multivariate Cox regression. Results: A total of 125 epithelial ovarian cancer patients were enrolled as 38 patients with < 50% regression of CA 125, 41 patients with 50 - < 80% regression of CA 125 and 46 patients with ? 80% regression of CA 125. Survival analysis showed association between regression of CA 125 level and 3-year progression free survival (p < 0.001). Patients with ? 80% regression of CA 125 had better 3-year progression free survival than the 50 - < 80% and < 50% groups. [hazard ratio (HR) 50 - < 80% = 2.87 [95% confidence interval (CI): 0.90-9.13], HR < 50% = 5.34 [95%CI: 1.74-16.4] vs. ? 80% group].Conclusion: Pre-postoperative regression of CA 125 had associated with 3-year progression free survival in patients who underwent primary surgery in epithelial ovarian cancer. The ? 80% CA 125 declination group recorded better survival outcome than the 50 - < 80% and < 50% groups. |
