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Development of an Immunosorbent for the Removal of Atherogenic Lipoproteins from the Body in the Extracorporeal Circulation System |
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| รหัสดีโอไอ | |
| Creator | Saida Ruslanovna Gadzhieva, Madina Zaurovna Gerbekova, Jamila Kazbekovna Chotchaeva, Abdulakh Akhmetovich Nalgiev, Makhmud Bashirovich Yandiev, Irina Dmitrievna Kormiltseva, Khedi Aslambekovna Akhrieva, Mariia Mikhailovna Cherniakova, Madina Muslimovna Minatulaeva, Zelimkhan Zaindievich Mutsagov |
| Title | Development of an Immunosorbent for the Removal of Atherogenic Lipoproteins from the Body in the Extracorporeal Circulation System |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2565 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 13 |
| Journal No. | 11 |
| Page no. | 13A11K: 1-10 |
| Keyword | Cardiovascular diseases, Atherosclerotic vascular lesions, Cholesterol, immunosorbent |
| URL Website | http://TuEngr.com/Vol13-11.html |
| Website title | ITJEMAST V13(11) 2022 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | Currently, in Russia and in the world, cardiovascular diseases (CVD) occupy first place among the causes of mortality in the adult population. The traditional treatment of atherosclerosis, according to modern Russian and foreign recommendations, consists in reducing the level of low-density lipoprotein cholesterol (LDL cholesterol) with statins. The article will describe the developed sorbent with high specificity and is able to effectively remove atherogenic lipoproteins from blood plasma, while it is chemically neutral and relatively inexpensive to manufacture, which allows it to be used in the future in the procedure of therapeutic LDL apheresis for the treatment of severe hypercholesterolemia. The proposed immunosorbent will increase the level of specific capacity relative to antibodies to low-density lipoproteins, and the use of relatively inexpensive components and ready-made sets of antibodies in the process of its synthesis will ensure the economic attractiveness of the final product. |
