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Development of safety management system for Tenofovir disoproxil fumarate (TDF) in HIV patient at Klongluang Hospital Pathumthani province |
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| รหัสดีโอไอ | |
| Creator | Pasupen Sukkasem |
| Title | Development of safety management system for Tenofovir disoproxil fumarate (TDF) in HIV patient at Klongluang Hospital Pathumthani province |
| Contributor | Rattanaporn Awiphan, Nantawarn Kittikannakorn |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2562 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 15 |
| Journal No. | 3 |
| Page no. | 33-44 |
| Keyword | TDF, Tenofovir, HIV, renal toxicity |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences,IJPS |
| ISSN | 19050852 |
| Abstract | Tenofovir disoproxil fumarate (TDF) is a standard antiretroviral agent for HIV treatment and prevention currently used in Thailand, although one critical side-effect is its renal toxicity. Development of a drug safety system for the hospital might prevent and alleviate problems related with TDF use. Objective: to develop a tenofovir safety management based on lean principle, medication reconciliation, and trigger tool. Materials and methods: This action research was done in HIV clinic at Klongluang Hospital. Deming cycle (PDCA) was used and composed of 4 steps (1) conducting an operational plan for HIV clinic by 12 multidisciplinary staffs (2) working followed the plan and collecting data in 189 patients between 1 October to 30 November 2017 (3) monitoring once a month for 2 consecutive months for service time, frequency of drug-related problem and number of medication error (4) announcing a new standard guideline for HIV clinic Result: outcomes were (1) reducing waiting time for laboratory service for 16.36 and 19.86 minutes, and reduced unnecessary cost for 1,470 and 1,680 baht in the first and second month, respectively (2) medication reconciliation presented (2.1) 1 undocumented intentional discrepancy and 2 unintentional discrepancies (2.2) 6 drug-related problems (2.3) 6 medication errors; 5 in B-level and 1 in D-level (3) trigger tool of crisis renal function was alarmed 19 times ; which were from 13 drug-related problems, 3 medication errors; 2 in B-level and 1 in E-level (4) this process was satisfied by 87.28% of staffs this plan was purposed to patient care team and then it was approved for using in HIV clinic. Conclusion: Tenofovir safety management could reduce waste and prevent risk of medication error.Keywords |
