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Impact of Lead Exposure on Fecal Microbiome in Workers at a PVC Manufacturing Plant in Rayong Province, Thailand |
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| รหัสดีโอไอ | |
| Creator | 1. Chatchawan Praditwongsin 2. Sumeth Wongkiew |
| Title | Impact of Lead Exposure on Fecal Microbiome in Workers at a PVC Manufacturing Plant in Rayong Province, Thailand |
| Publisher | Thai Society of Higher Education Institutes on Environment |
| Publication Year | 2567 |
| Journal Title | EnvironmentAsia |
| Journal Vol. | 17 |
| Journal No. | 3 |
| Page no. | 1-16 |
| Keyword | Fecal microbiome, Industrial safety, Lead exposure, Microbial biomarkers, Occupational health |
| URL Website | http://www.tshe.org/ea/index.html |
| Website title | EnvironmentAsia |
| ISSN | 1906-1714 |
| Abstract | Lead exposure in industrial settings poses significant health risks. The relationshipbetween lead exposure and changes in the fecal microbial community remains largelyunexplored while its adverse effects on human health are well documented, therebycreating a crucial gap in the understanding of its broader health implications. This studyinvestigated the fecal microbiota among workers in a lead-using polyvinyl chloridefactory, comparing those with blood lead levels (BLLs) above and below 3.06 ?g/dLand between lead-exposed and nonexposed groups. Results revealed a strong associationbetween lead exposure and BLLs, notably at BLLs of 3.06?g/dL, with significantshifts observed at a threshold of < 10 ?g/dL. BLLs associated with alterations in thefecal microbiome. Key genera, such as Blautia, Dorea, Streptococcus, Collinsella, andBifidobacterium, were notably affected, indicating the influence of lead on gut microbiotaand potential health implications. This study identified specific microbial biomarkersof lead exposure, including an increased presence of Blautia and Streptococcus and adecrease in Bifidobacterium in exposed workers. These insights provide avenues fordeveloping noninvasive diagnostics for detecting lead exposure. The results highlight theneed for protective measures against lead exposure in the workplace and reveal the useof the fecal microbiome as a sensitive indicator of environmental pollutants, supportingimproved safety protocols and monitoring practices in industrial environments, althoughfurther research with larger cohorts is required. |
