รหัสดีโอไอ 10.14455/TSB.res.2019.44
Title Molecular Epidemiology of Carbapenem Resistance Among Multidrug-resistant Pseudomonas aeruginosa isolated Clinically in Tertiaries Care Centers, Southern Thailand
Creator Phanvasri Saengsuwan
Contributor 1. Kamonnut Singkhamanan
2. Narongdet Kositpantawong
3. Natnicha Ingviya
4. Wichien Patugkaro
Publisher The Thai Society for Biotechnology
Publication Year 2019
Keyword Epidemiology ,Metallo-?-Lactamase ,Multidrug Resistance ,Pseudomonas aeruginosa
Abstract Pseudomonas aeruginosa is one of potent opportunistic nosocomial human pathogen that shows resistance to a multiple class of antibiotics with carbapenems being the most potent inhibitor of P. aeruginosa. This study aimed to investigate the prevalence of metallo-?-lactamases (MBLs) genes and antimicrobial susceptibilities of P. aeruginosa isolated in two tertiaries care hospitals of Songkhla Province. A total number of 209 P. aeruginosa isolates were collected between August 2015 and December 2016 from various clinical samples in two tertiaries care hospitals of Songkhla Province. Antibiotic susceptibility was determined using the disk diffusion method. MBLs genes were detected by multiplex-PCR and blasted. Out of 209 P. aeruginosa, 198 ( 94. 7%) was carbapenem- resistant isolates. The susceptibility rate of P. aeruginosa toward polymyxin B and Amikacin was 100% and 48.3% respectively. The highest of Pseudomonas infections were found in sputum 111 (53.1%), urine 37 (17.7%) and secretions 17 (8.1%) of P. aeruginosa isolates. It was also found that the rate of multidrug resistance P. aeruginosa infection was 36.4% in the medical ward, 20.1% in ICU and 12.9% in surgical wards. The most dominant MBLs genes among P. aeruginosa isolates was blaDIM (53.6%), while the prevalence of blaVIM, blaIMP and blaAIM were 29.2%, 12.4% and 9.6% respectively, whereas blaoxa48 was detected in only 9.6% of carbapenemase-positive isolates. The results showed that the prevalence of multidrug resistance was high and the presence of more than one blaMBLs gene in P. aeruginosa isolates to emphasize the challenge to therapeutic treating emerging.
Language EN
URL Website http://tsb2019.com/
Website title The 31st Annual Meeting of the Thai Society for Biotechnology and International Conference (TSB 2019)
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บรรณานุกรม

Phanvasri Saengsuwan และผู้แต่งคนอื่นๆ. (2019) Molecular Epidemiology of Carbapenem Resistance Among Multidrug-resistant Pseudomonas aeruginosa isolated Clinically in Tertiaries Care Centers, Southern Thailand. The Thai Society for Biotechnology:ม.ป.ท.
Phanvasri Saengsuwan และผู้แต่งคนอื่นๆ. 2019. Molecular Epidemiology of Carbapenem Resistance Among Multidrug-resistant Pseudomonas aeruginosa isolated Clinically in Tertiaries Care Centers, Southern Thailand. ม.ป.ท.:The Thai Society for Biotechnology;
Phanvasri Saengsuwan และผู้แต่งคนอื่นๆ. Molecular Epidemiology of Carbapenem Resistance Among Multidrug-resistant Pseudomonas aeruginosa isolated Clinically in Tertiaries Care Centers, Southern Thailand. ม.ป.ท.:The Thai Society for Biotechnology, 2019. Print.