|Title||Gut microbiota alteration along gastrointestinal tract in SLE (systemic lupus erythematosus)|
|Creator||1. Piraya Chatthanathon
2. Naraporn Somboona
|Publisher||The Thai Society for Biotechnology|
|Keyword||Gastrointestinal Tract ,Gut Microbiota ,Systemic Lupus Erythematosus|
|Abstract||1. The balance of microbiological ecology in the intestine (homeostasis) is essential for health. Dysbiosis of gut microbiota and diversity can lead to metabolic disorders and inappropriate immune responses, hence were reported to be associated with many diseases, including systemic lupus erythematosus (SLE), a chronic autoimmune disease. Because differences of physicochemical conditions in each intestinal section (duodenum, jejunum, ileum, cecum and colon) affect the composition of gut microbiota. This study we firstly reported gut microbiota composition along each section of mouse gastrointestinal tract comparing between lupus-prone mice by genetic FcGRIIb knockout and agedmatched healthy mice, at 4 months ( preclinical SLE) and 11 months (established SLE) of ages, to identify potentially beneficial and harmful bacteria. Gut microbiota were different in bacterial composition and diversity. The cecum and colon had the most significant differences between healthy and disease. In disease group, f_S24-7_unclassified, Anaerostipes, Lactobacillus, Sutterella, Allobaculum, Adlercreutzia and Bifidobacterium, as potential beneficial bacteria, decreased
2. whereas Mucispirillum, Oscillospira, f_Lachnospiraceae_ unclassified, Alistipes, and Sporobacter, as potential harmful bacteria, increased.
|Website title||The 31st Annual Meeting of the Thai Society for Biotechnology and International Conference (TSB 2019)|