|
Phytochemical study of Diospyros collinsae stems |
|---|---|
| รหัสดีโอไอ | |
| Title | Phytochemical study of Diospyros collinsae stems |
| Creator | Buntita Bumroong |
| Contributor | Witchuda Thanakijcharoenpath |
| Publisher | Chulalongkorn University |
| Publication Year | 2554 |
| Keyword | Diospyros collinsae, Diospyros collinsae -- Analysis, Phytochemicals, Botanical chemistry, Plasmodium falciparum, Breast -- Cancer -- Treatment, Lungs -- Cancer -- Treatment, พลับยอดดำ, พลับยอดดำ -- การวิเคราะห์, สารพฤกษเคมี, พฤกษเคมี, พลาสโมเดียมฟัลซิปารัม, เต้านม -- มะเร็ง -- การรักษา, ปอด -- มะเร็ง -- การรักษา |
| Abstract | Phytochemical study of the stems of Diosyros collinsae Craib (family Ebenaceae) led to the isolation of four triterpenoids, namely friedelin, lupeol, betulin and betulinic acid, two stilbenoids, diptoindonesin D and diptoindonesin G, together with a mixture of β-sitosterol and stigmasterol. Identification of the isolated compounds has been accomplished by spectroscopic analyses, including UV, IR, MS and NMR, and comparison with previously reported data. Diptoindonesin G exhibited antimalarial activity against Plasmodium falciparum with an IC₅₀ value of 6.88 µg/ml as well as cytotoxic activity against human small-cell lung cancer (NCI-H187) and breast adenocarcinoma (MCF-7) cell lines with IC₅₀ values of 1.94 and 43.28 µg/ml, respectively. The present study provided the first evidence for the production of stilbenoids in Diospyros Species. |
| URL Website | cuir.car.chula.ac.th |
