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Serum proteomic profile, pre- and post-treatemnt, in chronic hepatitis b patients treated by peg-interferon alfa-2b. |
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| รหัสดีโอไอ | |
| Title | Serum proteomic profile, pre- and post-treatemnt, in chronic hepatitis b patients treated by peg-interferon alfa-2b. |
| Creator | Sunida Kuakarn |
| Contributor | Nattiya Hirankarn, Pisit Tangkijvanich |
| Publisher | Chulalongkorn University |
| Publication Year | 2554 |
| Keyword | Hepatitis B virus -- Treatment, Hepatitis B virus -- Patients, Proteomics, ไวรัสตับอักเสบบี -- การรักษา, ไวรัสตับอักเสบบี -- ผู้ป่วย, โปรตีโอมิกส์ |
| Abstract | Chronic hepatitis B (CHB) virus infection may develop to liver fibrosis, cirrhosis, and hepatocellular carcinoma, and the disease remains a public health problem worldwide. Immunomodulatory therapies such as pegylated interferon is a major approach for the treatment of CHB patients but only 30% of them response to IFN type I treatment. Proteomic approach was employed to analyze the serum proteome in CHB patients receiving PEG-Interferon alfa-2b to predict treatment response. Nineteen patients with HBeAg + CHB were included. These patients were followed up for more than 3 years after treatment and were defined as sustained responders (n=9) and non responders (n=10). The 2-DE and MS/MS analysis were performed to compare the serum proteome before, after initial PEG-Interferon alfa-2b treatment for 24 weeks and 48 weeks. Quantitative intensity of 2-D gel from patients of the two groups before treatment showed 7 differentially expressed proteins. In addition, 13 protein spots were found to significantly changed in sustained responders, and 6 protein spots significantly changed at the end of the 24-week in nonresponders. These proteins are including CD5 antigen-like precursor, α-2-HS-glycoprotein and Apolipoprotein A-I. Functional characterizations of all proteins with respect to immunity protection, lipid metabolism, and acute phase protein. |
| URL Website | cuir.car.chula.ac.th |
