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Phytochemical study of maerua siamensis roots |
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| รหัสดีโอไอ | |
| Title | Phytochemical study of maerua siamensis roots |
| Creator | Nawarat Chadchen |
| Contributor | Rutt Suttisri |
| Publisher | Chulalongkorn University |
| Publication Year | 2553 |
| Keyword | Capparaceae, Botanical chemistry, แจง (พืช), พฤกษเคมี |
| Abstract | Chemical investigation of the roots of Maerua siamensis (Kurz) Pax. (family Capparidaceae) led to the isolation of two new indole alkaloids named 7-hydroxy-6-methoxycyclobrassinone and 7-hydroxycyclobrassinone, together with three known compounds i.e. β-sitosterol, vanillin and lupeol. The structures of these isolated compounds were determined by spectroscopic analyses, including UV, IR, MS and NMR, and comparison with previously reported data. 7-Hydroxy-6-methoxycyclobrassinone was strongly active (IC50 = 1.51 µg/ml), while 7-hydroxycyclobrassinone was moderately active (IC50 = 8.31 µg/ml), against human small-cell lung cancer cell line (NCI-H187). In addition, 7-hydroxy-6-methoxycyclobrassinone also exhibited anti-tuberculosis activity against Mycobacterium tuberculosis with a minimum inhibitory concentration of 25 µg/ml. |
| URL Website | cuir.car.chula.ac.th |
