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Age-associated with Endometrial Intraepithelial Neoplasia and Endometrial Carcinoma in Patients with Abnormal Uterine Bleeding |
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| รหัสดีโอไอ | |
| Creator | Phitsinee sabyeying |
| Title | Age-associated with Endometrial Intraepithelial Neoplasia and Endometrial Carcinoma in Patients with Abnormal Uterine Bleeding |
| Contributor | Thitinant Samutchaikij, Duangporn Rattanalappaiboon, Chayanid Detwongya |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2568 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 33 |
| Journal No. | 2 |
| Page no. | 95-103 |
| Keyword | age, endometrial intraepithelial neoplasia, endometrial cancer, abnormal uterine bleeding, endometrial biopsy |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To determine the age cut-off for endometrial biopsy in women with abnormal uterine bleeding to detect endometrial intraepithelial neoplasia and endometrial carcinoma in patients with abnormal uterine bleeding.Materials and Methods: A total of 1,384 women presenting with abnormal uterine bleeding underwent endometrial biopsy at Maharat Nakhon Ratchasima Hospital between July 1, 2021, and June 30, 2023. This retrospective cohort study collected age and other risk factors of endometrial intraepithelial neoplasia and endometrial carcinoma, then calculated sensitivity, specificity, negative likelihood ratio, area under the curve (AUC) of each age cut-off and conducted multivariable logistic regression. Results: The age group ? 45 years showed a moderate impact negative likelihood ratio (0.14, 95% confidence interval 0.07 - 0.31) and higher AUC (0.91) compared to other age groups, with a sensitivity of 94.17% and a specificity of 41.06%. The risk factors including age ? 45 years, nulliparity, menopause status, diabetes mellitus, polycystic ovarian syndrome, endometrial thickness of 4 and 7 mm or thicker were significantly associated with endometrial intraepithelial neoplasia and endometrial carcinoma. Conclusion: Consider endometrial biopsy for screening of endometrial intraepithelial neoplasia and endometrial carcinoma in women aged 45 or older with abnormal uterine bleeding or those under 45 with risk factors such as nulliparity, diabetes mellitus, menopausal status, polycystic ovarian syndrome, and endometrial thickness of 4 and 7 mm or thicker. |
