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Comparison of Clinical Characteristic and Survival Outcomes between Clear Cell and Non-Clear Cell Ovarian Cancer |
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| รหัสดีโอไอ | |
| Creator | Phornsawan Wasinghon |
| Title | Comparison of Clinical Characteristic and Survival Outcomes between Clear Cell and Non-Clear Cell Ovarian Cancer |
| Contributor | Kobkarn Champoonot, Auttaya Ratakaew, Pallop Pongsuthirak |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2566 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 31 |
| Journal No. | 1 |
| Page no. | 21-32 |
| Keyword | clear cell adenocarcinoma, epithelial ovarian cancer, survival analysis |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To compare clinical characteristics and survival outcomes between women with clear cell carcinoma (CCC) and non-clear cell (NCC) epithelium ovarian cancer. Materials and Methods: A retrospective cohort study was conducted on 220 Epithelial ovarian cancer (EOC) patients at Buddhachinaraj Hospital between January 1999 and May 2017. The patient data were retrieved from medical records. The patient characteristic, operative findings, histologic types, chemotherapy, time of recurrence, and follow-up time were analyzed. The medical records were comprehensively reviewed. The Kaplan-Meier method and Cox regression were employed in the survival analyses.Results: A total of 220 EOC patients were eligible in the study, comprising 63 cases of CCC and 150 cases of NCC. Patients with CCC were more presented stage I and met optimal cytoreduction (p < 0.005). The progression-free survival (PFS) and overall survival (OS) were not statistically different between CCC and NCC when analyzed in all stages. However, PFS and OS were significantly different when classified EOC into three groups: NCC type I, type II EOC, and CCC. In stage I, CCC had better PFS (p = 0.007), but OS was no significant difference (p = 0.279). In stage II-IV, CCC had a trend toward poorer 5-year OS than type II EOC. The optimal surgery and complete course of platinum-based chemotherapy were associated with better survival outcomes in patients with epithelial ovarian cancer (p < 0.001). Conclusion: The prevalence of CCC was 29.65% of EOC patients, and the majority found stage I. The PFS and OS were not statistically different between CCC and NCC. |
