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The efficacy of povidone-iodine and normal saline on excision wound in mice |
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| รหัสดีโอไอ | |
| Creator | Pataweekorn Ketkomol |
| Title | The efficacy of povidone-iodine and normal saline on excision wound in mice |
| Contributor | Supparit Pakdeethai, Watchara Chongsa, Tadsanee Punjanon, Suwichak Chaisit, Cherdsak Boonyong |
| Publisher | Rangsit University |
| Publication Year | 2566 |
| Journal Title | ๋Journal of Current Science and Technology |
| Journal Vol. | 13 |
| Journal No. | 1 |
| Page no. | 83-90 |
| Keyword | collagen production, excision wound, epidermis, histoarchitecture, mice, povidone-iodine, wound healing |
| URL Website | https://jcst.rsu.ac.th |
| ISSN | 2630-0656 |
| Abstract | In cleaning wounds, little attention has been given to the solutions, waiting for the natural process without the user agent, but these problems can cause chronic injuries and inflammation. Povidone-iodine is a tropical antiseptic agent that popularly used to prevent infection and aid healing of wounds. However, the effects of povidone-iodine on the histologic change of excision wound healing have not been reported. Therefore, the objective was to assess the histological influences of 10% povidone-iodine ointment on healing process of experiment excision wounds in mice. Albino ICR mice were randomly divided into two groups with six mice each; a normal saline-treated group and a povidone-iodine-treated group. Wounds were created in all mice and treated with normal saline or povidone-iodine once daily for 14 days. The wound areas were measured on days 2, 5, 8, and 14. Then, a percentage of wound contraction was calculated. The histoarchitecture of the wound was observed on days 14 by staining with hematoxylin-eosin and Masson’s trichrome. The results showed that the average percentage of wound contraction of the povidone-iodine-treated group was significantly higher than the normal saline-treated group on days 5, 8, and 14. The histoarchitecture studies of the povidone-iodine-treated group showed a thickening of the epidermis and dense deposition of collagen fiber when compared to the normal saline-treated group. These findings indicated that povidone-iodine treatment could accelerate the wound healing processes. |
