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Features of B. anthracis Vaccine Strains for the Production of Anthrax Vaccines |
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| รหัสดีโอไอ | |
| Creator | Lusine Tsaturyan, Oleg Sklyarov |
| Title | Features of B. anthracis Vaccine Strains for the Production of Anthrax Vaccines |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2565 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 13 |
| Journal No. | 12 |
| Page no. | 13A12K: 1-10 |
| Keyword | Anthrax, Vaccine, Immunogenicity, Safety, Strain, Virulence, Spores, Protective properties |
| URL Website | http://TuEngr.com/Vol13-12.html |
| Website title | ITJEMAST V13(12) 2022 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | This article presents the results of a comparative study of the cultural, morphological, biological and protective properties of current or proposed vaccine strains against anthrax B. anthracis 34F2, 55-VNIIVViM, STI-1, 1190-R - Stamatin, Pasteur, Shuya-15, 916- 1, No. 94, Mato, Ihtiman. All strains are attenuated. The mass fraction of spores of strains after cultivation on beef-peptone agar (MPA) was 9098%. ImD50 of vaccine strains for guinea pigs was: 55-VNIIVViM - 0.34; 34F2 and STI -1 - 0.58; Ihtiman - 0.76, Shuya-15, 916-1, No. 94, Mato- 1.71, 1190-R - Stamatin - 3.14; Pasteur - 0.05 million spores. B. anthracis strains 55-VNIIVViM, 34F2, STI-1 at a dose of 10 ImD50 and B. anthracis Pasteur strain at a dose of 5 ImD50 provided protection against infection by a culture of the control weakly virulent B. anthracis M-71 capsular strain at a dose of 1.0 million live spores of 100% immunized guinea pigs. |
