In vitro antioxidant capacity, total phenolic and flavonoid contents, and wound healing potential in Mangifera indica L. leaf extracts
รหัสดีโอไอ
Creator Panthip Rattanasinganchan
Title In vitro antioxidant capacity, total phenolic and flavonoid contents, and wound healing potential in Mangifera indica L. leaf extracts
Contributor Kittipat Sopitthummakhun, Wicharn Janwitayanuchit
Publisher Khon Kaen University, Thailand
Publication Year 2568
Journal Title Asia-Pacific Journal of Science and Technology
Journal Vol. 30
Journal No. 4
Page no. 14 (11 pages)
Keyword Mangifera indica L., human keratinocyte, wound healing activity, maceration, antioxidant capacity
URL Website https://apst.kku.ac.th/
Website title https://apst.kku.ac.th/in-vitro-antioxidant-capacity-total-phenolic-and-flavonoid-contents-and-wound-healing-potential-in-mangifera-indica-l-leaf-extracts/
ISSN 2539-6293
Abstract Mangifera indica L. is a rich source of biological active compounds, prominently Mangiferin, characterized by its glycosylated xanthone structure. This compound is abundant in various edible sources, such as mango, and exhibits diverse biological activities. Extensive investigation into Mangiferin has highlighted antioxidant, anti-inflammatory, antidiabetic, anticancer, and antimicrobial properties. In this study, Mangiferin extract was prepared through maceration in 80% ethanol, yielding 1,628 g from an initial dry leaf mass of 4,234 g of dried leaf material. The ethanolic extract showed notable torox equivalent antioxidant capacity (TEAC) values for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, measured at 0.32 ± 0.03 and 0.56 ± 0.01 mM Trolox equivalents per gram dry material, respectively. The ferric reducing ability power (FRAP) value was determined to be 6.95 ± 0.40 mM FeSO4 per milligram dry material. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays conducted on human adult calcium temperature (HaCaT) cell line indicated that concentrations ranging from 3.90 to 31.25 µg/mL did not significantly impact cell viability. Evaluation of the wound healing of the Mangiferin ethanolic extract demonstrates a consistent decrease in wound area for treated cells compared to untreated controls, with significant decreases observed after 48 hours (p < 0.05). These findings support the antioxidant and wound healing properties of the Mangiferin ethanolic extract, underscoring its therapeutic potential in promoting wound repair.
Asia-Pacific Journal of Science and Technology

บรรณานุกรม

EndNote

APA

Chicago

MLA

ดิจิตอลไฟล์

Digital File
DOI Smart-Search
สวัสดีค่ะ ยินดีให้บริการสอบถาม และสืบค้นข้อมูลตัวระบุวัตถุดิจิทัล (ดีโอไอ) สำนักการวิจัยแห่งชาติ (วช.) ค่ะ