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Electrospun chitosan/polyvinyl alcohol nanofibrous membrane loading curcumin to promote wound healing and improve antibacterial properties |
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| รหัสดีโอไอ | |
| Creator | Ngoc-Hanh Cao-Luu |
| Title | Electrospun chitosan/polyvinyl alcohol nanofibrous membrane loading curcumin to promote wound healing and improve antibacterial properties |
| Contributor | Bich-Thuyen Nguyen-Thi, Huynh-Vu-Thanh Luong, Lien-Huong Huynh, Thuy-Tien Tiet-Thi, Kim-Oanh Nguyen-Thi |
| Publisher | Khon Kaen University, Thailand |
| Publication Year | 2568 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 30 |
| Journal No. | 3 |
| Page no. | 4 (11 pages) |
| Keyword | Chitosan, Curcumin, Electrospinning method, Polyvinyl alcohol, Wound healing nanofibrous membranes |
| URL Website | https://apst.kku.ac.th/ |
| Website title | https://apst.kku.ac.th/electrospun-chitosan-polyvinyl-alcohol-nanofibrous-membrane-loading-curcumin-to-promote-wound-healing-and-improve-antibacterial-properties/ |
| ISSN | 2539-6293 |
| Abstract | Wound healing nanofiber membranes were successfully fabricated by electrospinning of chitosan (CS) and polyvinyl alcohol (PVA) solution in the presence of curcumin (CCM). As a results, the optimal material parameters included 2% (w/v) for the CS concentration, 8% (w/v) for the PVA concentration, 3% for the CCM concentration (by mass of CS), 3/7 for the CS/PVA volume ratio; the process parameters of 15 cm for the needle tip-to-collector distance, 15 kV for the applied voltage, and 0.1 mL/h for the solution flow rate. The obtained membranes exhibited the relatively uniform diameter fibers distributed from 200 to 450 nm, average diameter at 348.55 ? 51.48 nm, smooth fiber surface, and uniform fiber texture. The fourier transform infrared spectroscopy (FTIR) results demonstrated the presence of CCM in the CS/PVA/CCM membrane, thereby showing that the structure of CCM is not changed during the fabrication. In-vitro test showed that the amount of CCM released significantly from CS/PVA/CCM membrane during the first 6 hours (up to 80.28%), it was followed by maintain at a rather slow rate, and the maximum CCM released was 92.26% after 72 h. The prepared CCM membrane exhibits high antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Listeria monocytogenes) bacteria strain, which is an important property of wound healing membrane. Remarkably, CS/PVA/CCM nanofiber membrane accelabrates healing process in rats with incised wounds and demonstrates superior healing ability comparing to CS/PVA membrane and commercial bandages. In brief, CS/PVA/CCM nanofiber membrane is a potential wound dressing with good healing and high antibacterial properties. |
