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ANTI-DARK CIRCLE EYE AND ANTI-BAG EYE ACTIVE INGREDIENTS IN COSMETIC PRODUCTS |
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| รหัสดีโอไอ | |
| Creator | Thirapit Subongkot |
| Title | ANTI-DARK CIRCLE EYE AND ANTI-BAG EYE ACTIVE INGREDIENTS IN COSMETIC PRODUCTS |
| Publisher | Faculty of Pharmacy, Silpakorn University |
| Publication Year | 2560 |
| Journal Title | Thai Bulletin of Pharmaceutical Science (TBPS) |
| Journal Vol. | 12 |
| Journal No. | 1 (January-June)2017 |
| Page no. | 63-76 |
| Keyword | dark circle eyes, bag eyes, active ingredients, cosmetic products |
| ISSN | 1686-9540 |
| Abstract | Since the skin around the eyes is thinner than the others and blood vessels are very fragile, it is susceptible to discoloration. Dark circle eyes result from several causes such as skin accumulation of pigments which are heme, bilirubin and iron. These pigments occurred from hemoglobin degradation of red blood cells after leakage out of blood vessels. Dark circle eyes are also caused by abnormal melanin synthesis in the skin. Eye bag or puffiness results from plasma retention in the skin as a consequence of high permeability of blood vessels. The anti-dark circle eye and anti-bag eye active ingredients with various mechanisms have been developed for cosmetic products. The anti-dark circle eye active ingredients are chrysin, seaweed extract, fucan, galactan, vitamin K and plant extracts. To decrease dark circle eyes, chrysin stimulates bilirubin degradation enzyme while seaweed extract stimulates heme degradation enzyme. Fucan and galactan decrease dark circle eyes by reducing vascular permeability. However, the mechanism of vitamin K and plant extracts in dark circle eye reduction is still unknown. The anti-bag eye active ingredients are hesperidin methyl chalcone, acetyl tetrapeptide-5 and gallic acid derivatives. In order to decrease eye bag, hesperidin methyl chalcone reduces vascular permeability whereas acetyl tetrapeptide-5 inhibits glycation and vascular permeability. Gallic acid derivatives reduce eye puffiness by improving lymphatic circulation. The efficacy tests of anti-dark circle eye and anti-bag eye agents in human volunteers show good outcomes in most subjects. |
