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Neuron modelling for Alzheimerโs neuron condition in early,intermediate, and advanced stage using amyloid-betaand tau protein as parameters |
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| รหัสดีโอไอ | |
| Creator | 1. Jagruti Patil 2. Kruti Desai 3. Kashish Tilokani 4. Utkarsh Pancholi |
| Title | Neuron modelling for Alzheimerโs neuron condition in early,intermediate, and advanced stage using amyloid-betaand tau protein as parameters |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 2 |
| Page no. | 433-439 |
| Keyword | Alzheimer's disease, beta-amyloid protein, genetic mutation, neurons, tau protein |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Neurons are basic units of our nervous system used for communication between the brain and the body. Any disruptionin their structures or communication can result in several disorders like Dementia and Alzheimer's disease (A.D.). In this paper,we explore the alterations in neurons causing A.D. Due to specific genetic mutations, neurons release and accumulate tau proteinand beta-amyloid protein, thus hampering the communication process, leading to neuron death known as brain atrophy, andeventually shrinking the brain is the case in A.D. This paper discusses neuron modeling of a typical neuron and an Alzheimer'sneuron to understand the difference and progression of A.D. and the fact that once these equations are concluded, they could beused to control the brain through a brain-computer interface. Modeling of neurons enables exploring different parameters andunderstanding the behavior of a particular system, and finally, concluding to represent a biological activity mathematically. |
