|
Antibiotics related adverse drug reactions in Ethiopia |
|---|---|
| รหัสดีโอไอ | |
| Creator | 1. Hailye Birhane 2. Mathew George 3. Lincy Joseph 4. Mujahidu Islam 5. Damen H/Mariam 6. Vijender Singh |
| Title | Antibiotics related adverse drug reactions in Ethiopia |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 2 |
| Page no. | 415-420 |
| Keyword | antibiotics, adverse reactions, Ethiopia, retrospective study, spontaneous report |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Antibiotics are one of the most common drugs that can induce adverse drug reaction (ADR). A retrospective analysiswas conducted using suspected antibiotic-related ADR data collected from the Ethiopian Pharmacovigilance Center over a 5-yearperiod (2014-2019). There were a relatively large number of antibiotic-related ADRs (57.9%) containing 462 suspected drugsreported, with adults aged 18-64 (65.5%) and females (61.5%) predominating in the reported cases. Monotherapy and oral routeadministration were responsible for 85% and 83% of ADRs, respectively. Co-trimoxazole and amoxicillin were responsible formore than half of the reported ADRs and skin disorder was half of the affected system organ (SOC). Serious ADRs constituted26% of all reported ADRs. The outcome of the patient showed that (44.7%) of patients were completely recovered afterdiscontinuing the offending drug and additional intervention. The finding in this study suggests that antibiotic related ADRs are asignificant health problem for patients in Ethiopia and further health facility based research is suggested. |
