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The inhibitory effect of crude water extract of Musa sapientuminflorescence on Streptococcus mutans |
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| รหัสดีโอไอ | |
| Creator | 1. Nattapon Rotpenpian 2. Uraiwan Sungchum 3. Sissada Tannukit 4. Suwanna Jitpukdeebodintra |
| Title | The inhibitory effect of crude water extract of Musa sapientuminflorescence on Streptococcus mutans |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 1 |
| Page no. | 236-241 |
| Keyword | Streptococcus mutans, Musa sapientum, biofilm formation, acid production |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Streptococcus mutans (S. mutans) has virulence factors involved in the pathogenesis of dental caries. The aim of thisstudy was to investigate the inhibitory effects of the crude water extracts from Musa sapientum inflorescence (MSI water extract)on S. mutans. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were determined by thebroth microdilution method. In addition, the inhibitory effects on glycosyltransferase activity (GTFs) of S. mutans, biofilmformation, and acid production were examined. The MIC and MBC of MSI water extract were 62.5 and 125 mg/ml, respectively,tested with 0.05% v/v chlorhexidine as the positive control. At 2MIC, the viability of S. mutans was reduced by at least 2.3 logCFU/ml compared with the positive control. MSI water extract at MIC and sub-MIC showed more than 50 percent inhibitoryeffect on GTFs. MSI water extracts at 1/2MIC, 1/4MIC and 1/8MIC exhibited attenuation of the acid production in a dosedependent manner. This results indicate that MSI water extract exhibits inhibitory effects on virulence factors of S. mutans. |
