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A novel synthesis of stabilized molecularly imprinted polymer forelectropolymerization to detect bismethoxycurcumin from curcuminoid |
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| รหัสดีโอไอ | |
| Creator | 1. Meyliana Wulandari 2. Nofrizal Nofrizal 3. Syed Azhar Syed Sulaiman |
| Title | A novel synthesis of stabilized molecularly imprinted polymer forelectropolymerization to detect bismethoxycurcumin from curcuminoid |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 6 |
| Page no. | 1524-1531 |
| Keyword | bisdemethoxycurcumin, electrosynthesis, functional monomer, molecularly imprinted polymer, quartz crystal microbalance |
| URL Website | https://sjst.psu.ac.th/ |
| ISSN | 0125-3395 |
| Abstract | The purpose of this study is to synthesize a molecularly imprinted polymer (MIP) for use in an electropolymerizationapproach to separate bisdemethoxycurcumin (BDMC) from curcuminoid. The template molecule used is 3-(4-hydroxyphenyl)propionic acid (HPPA) serving as a water soluble template with a similar molecular structure to BDMC. Pyrrole is used as thefunctional monomer (FM). The synthesized ultrathin polymer was reproducible and homogeneous, prepared with a goldelectrode. An optimization of conditions to remove the template from the ultrathin film was carried out. The analyte rebindingwas investigated with Quartz Crystal Microbalance. Fourier Transform Infra-Red characterized the functional groups before andafter washing out the template. An electrodeposition of polymers was achieved at -400 Hz of thickness in 1000 s. The rebindingstudy showed that adsorption capacity of MIP was higher than that of NIP. Regarding selectivity the BDMC had a higher bindingaffinity to the MIP than to Curcumin (CUR). MIP sensor demonstrated the ability to discriminate target analyte against a veryclose analog, curcumin, and exhibited good recovery for use in herbal medicine. |
