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Tunable drug loading and release from blended chitosan/silkfibroin-based daily disposable contact lenses |
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| รหัสดีโอไอ | |
| Creator | 1. Rachasit Jeencham 2. Martin Humenik 3. Manote Sutheerawattananonda 4. Duy Toan Pham 5. Waree Tiyaboonchai |
| Title | Tunable drug loading and release from blended chitosan/silkfibroin-based daily disposable contact lenses |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 5 |
| Page no. | 1373-1380 |
| Keyword | tunable drug release, contact lenses, chitosan, silk fibroin |
| URL Website | https://sjst.psu.ac.th/ |
| ISSN | 0125-3395 |
| Abstract | Recently, chitosan/regenerated silk fibroin (CS/SF) films have been developed for daily disposable contact lenses. Thisstudy further explored the versatility of using CS/SF films in contact-lens-based ophthalmic delivery for multiple charged drugs.The selected model drugs, the negatively charged 5(6)-carboxyfluorescein (CF), the zwitterion rhodamine B (RB), and the noncharged acetaminophen (APAP), were individually loaded into the CS/RSF films by soaking. The non-charged APAP couldnot be loaded into the CS/SF films, whereas the charged CF and RB were successfully loaded. The drug loading capacityincreased with soaking time and reached its equilibrium at 3 h. Furthermore, the drug loading capacity and release characteristicscould be controlled by adjusting the CS/SF ratio in the film, which is useful for tailoring various treatments. The loading capacityand release duration of the negatively charged CF increased with CS content, while those of the zwitterion RB increased withSF content. In addition, a prolonged drug release exceeding 12 h could be obtained for both drugs. In summary, the CS/SF filmsare promising biomaterials for contact-lens-based ophthalmic delivery of various charged drugs, which is beneficial for reducingthe drug side effects and administration frequency. |
