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Domperidone loaded Caesalpinia pulcherrima galactomannan-basedmicrospheres for nasal administration: In-vitro and In-vivo studies |
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| รหัสดีโอไอ | |
| Creator | 1. Nilima Thombre 2. Yogita Patil |
| Title | Domperidone loaded Caesalpinia pulcherrima galactomannan-basedmicrospheres for nasal administration: In-vitro and In-vivo studies |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 5 |
| Page no. | 1314-1322 |
| Keyword | Domperidone, Caesalpinia pulcherrima galactomannan, mucoadhesive microspheres, NDDS, spray drying |
| URL Website | https://sjst.psu.ac.th/ |
| ISSN | 0125-3395 |
| Abstract | Caesalpinia pulcherrima galactomannan (CPG) based Domperidone (DOM) spray-dried mucoadhesive microspheresfor nasal administration were developed using 23 FD to avoid first-pass metabolism, with improved therapeutic efficiency fortreatment of nausea and vomiting as an alternative therapy to parenterals. Concentration of polymer, inlet temperature, andaspirator speed were selected for manipulated independent variables, whereas %entrapment efficiency and %drug release werethe dependent variables. The developed microspheres were evaluated for particle size, entrapment efficiency, zeta potential,swelling ability, in-vitro mucoadhesion, in-vitro drug release, and DSC and XRD responses. The developed formulation wasstudied in rabbit for screening nasal absorption potential. The formulation possesses in vitro drug release from 62.87% to94.80%, entrapment efficiency from 89.69% to 98.64%, and mucoadhesion from 73.6 to 82.47% across goat nasal mucosa. Invivo study in rabbit showed that DOM microspheres provide quick drug absorption, and enhanced bioavailability of drug uponnasal administration as compared to oral route. Thus, the developed DOM based formulation can be alternative to oral andparenteral formulations. |
