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Effect of oral moisturizers containing chitosan and poloxamer 407 on biofilm formation of Candida species and Streptococcus mutans: in vitro |
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| รหัสดีโอไอ | |
| Creator | 1. Wilairat Sarideechaigul 2. Suwipa Ungphaiboon 3. Hathaipan Ardpolthai 4. Arnanee Jehsama-ae 5. Kulrudee Sangsuttiwongsa 6. Suwimol Taweechaisupapong |
| Title | Effect of oral moisturizers containing chitosan and poloxamer 407 on biofilm formation of Candida species and Streptococcus mutans: in vitro |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 5 |
| Page no. | 1298-1305 |
| Keyword | oral moisturizer, chitosan, poloxamer 407, Candida species, Streptococcus mutans |
| URL Website | https://sjst.psu.ac.th/ |
| ISSN | 0125-3395 |
| Abstract | Oral moisturizers are topical agents which can directly relieve xerostomia and hyposalivation. This study evaluated theeffects of three newly developed oral moisturizers (1) a formulation containing 0.5% chitosan (CHI) with 15% poloxamer 407(P407), (2) a formulation containing only 0.5% CHI, and (3) a formulation containing only 15% P407, on adhesion and biofilmformation of three Candida strains, i.e., Candida albicans DMST 5815, Candida krusei and Candida tropicalis from clinicalisolates and Streptococcous mutans DMST 18777, compared with a commercially available oral moisturizer by using crystalviolet assay. The results showed, in contrast to the commercial oral moisturizer, a significant reduction of Candida species and S.mutans adhesion and biofilm formation after exposure to the three formulations (P < 0.05). The formulation containing CHI withP407 exhibited the strongest anti-adhesion and anti-biofilm properties against Candida species. At the same time, thesecombinations of CHI with P407 formulation may not be good for against S. mutans adhesion and biofilm. In contrast, theformulation containing only CHI displayed strikingly stronger anti-adhesion and anti-biofilm effects against S. mutans than theCHI with P407 formulation. This evidence confirms the great potential of anti-adhesion and anti-biofilm properties of CHIagainst Candida species and S. mutans.Keywords: oral moisturizer, chitosan, poloxamer 4 |
