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Association of type 2 diabetes and hepatitis C virus infection in Pakistani population: A meta-analysis |
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| รหัสดีโอไอ | |
| Creator | 1. Sher Zaman Safi, Humaira Shah, Muhammad Imran, Mamoon Noreen, Zahira Latif, Fouzia Rehman, Abid Ali 2. Naushad Muhammad 3. Yasir Waheed 4. Talha Bin Emran 5. Shah Alam Khan 6. Vorticella Subramaniyan 7. Ikram Shah Bin Ismail |
| Title | Association of type 2 diabetes and hepatitis C virus infection in Pakistani population: A meta-analysis |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 5 |
| Page no. | 1193-1200 |
| Keyword | HCV, diabetes, meta-analysis, HCV-diabetes association, liver diseases |
| URL Website | https://sjst.psu.ac.th/ |
| ISSN | 0125-3395 |
| Abstract | In Pakistan and other developing countries, the available data on the association of T2DM and HCV is limited. Wetherefore made an attempt to report the association of HCV and diabetes in Pakistani population through this meta-analysis.HCV and diabetes related studies were identified using various key words, from a number of databases including CINAHL,PubMed, Web of Science and Embase. Using RevMan5, the main outcome was regarded as type 2 diabetes associations withhepatitis c virus infection in Pakistan. Independent analyses were made for "HCV in diabetic patients" and "diabetes cases inhepatitis C virus patients". Using random effect model, odds ratios were calculated with 95% CIs (dichotomous data). I2 statisticswere used to calculate heterogeneity. From a total of 53 studies, we finally selected 6 studies for the meta-analysis. Using randomeffects model, hepatitis c virus patients in 3 studies (n = 1,902) demonstrated that HCV is a risk factor in developing diabetes,contrary to patients with no HCV infection (OR 0.01, 95% CI: 0.00-0.06, I2 = 0%; RR 0.01, 95% CI: 0.00-0.07, I2 = 0%). Theremaining 3 studies (n = 13,710) had reported HCV infections in type 2 diabetic patients and patients with no diabetes. Similarly,our meta-analysis revealed higher prevalence of HCV infections in patients with type 2 diabetes (OR 0.7, 95% CI: 0.17-0.42, I2= 32%; RR 0.30, 95% CI: 0.20-0.46, I2 = 32%) as compared to patients with no type 2 diabetes mellitus. Our meta-analysisdemonstrates a significant link between HCV and T2DM. Further studies are recommended with adequate sample sizes |
