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Antibacterial activity of ajwain oil on multidrug-resistantEnterobacteriaceae isolated from human faeces |
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| รหัสดีโอไอ | |
| Creator | 1. Nalin Wongkattiya 2. Phanchana Sanguansermsri 3. Kanit Assawatheptawee 4. Pannika Ritvirool Niumsup 5. Ian Hamilton Fraser 6. Donruedee Sanguansermsri |
| Title | Antibacterial activity of ajwain oil on multidrug-resistantEnterobacteriaceae isolated from human faeces |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 3 |
| Page no. | 785-793 |
| Keyword | ajwain oil, thymol, antibacterial activity, multidrug-resistant bacteria |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | The aims of this study were to evaluate the effects of ajwain oil on multidrug-resistant (MDR) Enterobacteriaceaeisolated from human faeces, the mode of action, and the active components. The studies also include the methicillin-resistantStaphylococcus aureus (MRSA). The ajwain oil showed broad spectrum and strong antibacterial activity against all the bacteriatested. The ajwain oil contained at least nine chemical compounds, and thymol was shown to be the most active componentagainst all tested bacteria. Time-kill assay showed bactericidal effect and over 2 log reduction of MRSA and MDREnterobacteriaceae after exposure to the ajwain oil for 30 and 10 minutes, respectively (1x, 2x, and 4x MIC). The scanningelectron micrograph of MRSA and MDR Escherichia coli demonstrated bacterial cellular destruction after one-hour exposure tothe 1x MIC of ajwain oil. Our results suggest that the application of ajwain oil may have potential for control and treatment ofantibiotic resistant bacteria. |
