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Identification of highly potent ฮฑ-glucosidase inhibitorsfrom Garcinia schomburgkiana and molecular docking studies |
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| รหัสดีโอไอ | |
| Creator | 1. Thi My Lien Do 2. Nguyen-Minh-An Tran 3. Thuc-Huy Duong 4. Preecha Phuwapraisirisan 5. Nakorn Niamnont 6. Suttira Sedlak 7. Kewalin Inthanon 8. Jirapast Sichaem |
| Title | Identification of highly potent ฮฑ-glucosidase inhibitorsfrom Garcinia schomburgkiana and molecular docking studies |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2564 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 6 |
| Page no. | 1597-1603 |
| Keyword | Clusiaceae, Garcinia schomburgkiana, ฮฑ-glucosidase inhibition, molecular docking calculation |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Twenty-two compounds (1-22) were isolated from the stems and twigs of Garcinia schomburgkiana. NMR, IR, UV,and MS were used for structural elucidation, and comparisons were made with previous reports. Compound 1 exhibited the mostpotent ฮฑ-glucosidase inhibition (IC50 0.31 ยฑ 0.7 ฮผM), outperforming the positive control (acarbose). Molecular docking resultsshowed that the phenolic hydroxyl groups on the phenyl rings linked with active receptor sites on the protein in 1. By preventingthe duplication of DNA sequences, Compound 1 is an excellent inhibitor of the ฮฑ-glucosidase enzyme, and represents a potentialnovel class of ฮฑ-glucosidase inhibitor. |
