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The effects of ethanolic extract of Okra fruit, Abelmoschus Esculentus(L.) Moench on cellular senescence in aging neuron |
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| รหัสดีโอไอ | |
| Creator | 1. Pichaya Jumnongprakhon 2. Krittalak Pasakawee 3. Panida Banjongsinsiri 4. Nowwapan Donrung 5. Supawadee Daodee 6. Pennapa Chonpathompikunlert |
| Title | The effects of ethanolic extract of Okra fruit, Abelmoschus Esculentus(L.) Moench on cellular senescence in aging neuron |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2564 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 5 |
| Page no. | 1367-1373 |
| Keyword | antioxidant, cellular senescence, cellular dysfunction, neurodegeneration, okra fruit |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Cellular senescence is characterized by morphological and metabolic changes with emerging neurodegeneration.Recently, senescence has been described as having excessive amount of reactive oxygen species (ROS) and over-activation ofsenescence associated ?-galactosidase (SA-?-gal) prior mediated loss of synaptic plasticity. The purpose of this study was toevaluate the therapeutic effects of ethanolic extract of Okra fruit (OKR) on neuronal aging. SK-N-SH cells were pre-incubatedwith hydrogen peroxide (H2O2) for 4 h and then treated with 10, 25, 50, or 75 ?g/mL OKR for 24 h. The results demonstratedthat OKR significantly promoted cell viability with reduction of ROS content and SA-?-gal positive cells. Additionally, thesynaptic plasticity was also improved by inhibiting the AChE activity in OKR administration compared to aging neurons.Interestingly, the OKR was comparable to N-acetylcysteine (NAC). Hence, we propose that OKR could alleviate the negativeresponses to aging in neurons. |
