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Cholesterol-lowering activity and functional characterizationof lactic acid bacteria isolated from traditional Thai foodsfor their potential used as probiotics |
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| รหัสดีโอไอ | |
| Creator | 1. Narathip Puttarat 2. Boonyarut Ladda 3. Anongnard Kasorn 4. Somboon Tanasupawat 5. Malai Taweechotipatr |
| Title | Cholesterol-lowering activity and functional characterizationof lactic acid bacteria isolated from traditional Thai foodsfor their potential used as probiotics |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2564 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 5 |
| Page no. | 1283-1291 |
| Keyword | cholesterol-lowering activity, bile salt hydrolase, functional characteristics, lactic acid bacteria, probiotics |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Hypercholesterolemia is one of the major risk factors related to global health problems. Probiotics with cholesterollowering activity can improve cholesterol metabolism without any adverse effects. In this study, seventeen lactic acid bacteria(LAB) isolated from traditional Thai foods exhibited the ability to produce bile salt hydrolase (BSH) and assimilate cholesterol.From these isolates, Lactobacillus reuteri TF-7, Enterococcus faecium TF-18, and Bifidobacterium animalis TA-1 were selectedfor cholesterol-lowering LAB candidates due to their robust cholesterol reduction activity with different genera. Furthermore,these strains had proven to be safe and expressed different characteristics. L. reuteri TF-7 could produce gamma-aminobutyricacid (GABA), whereas B. animalis TA-1 was the most potent antioxidant strain. Moreover, all three LAB strains could tolerateunder the acid and bile salt conditions, and adhered to the intestinal epithelial cells. According to these findings, three LABstrains are potential cholesterol-lowering probiotics, which can be applied as probiotic supplements. |
