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Changes of FSH and LH receptors expressions in rat testis aftermethamphetamine exposure |
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| รหัสดีโอไอ | |
| Creator | 1. Paweena Kaewman 2. Sutisa Nudmamud-Thanoi 3. Samur Thanoi |
| Title | Changes of FSH and LH receptors expressions in rat testis aftermethamphetamine exposure |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2564 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 4 |
| Page no. | 1018-1021 |
| Keyword | FSH receptor, LH receptor, methamphetamine, testis |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Methamphetamine (METH), the most widely used psychostimulant in Thailand, has been reported to have harmfuleffects on testicular functions and sperm quality, but its mechanisms are still unclear. Since follicle?stimulating hormone (FSH)and luteinizing hormone (LH) play important roles in spermatogenesis through their receptors in testis, we therefore focused onthe changes in FSH and LH receptors after METH administration. Male SpragueDawley rats were divided into control andMETH?administrated groups. The mRNA and protein expressions were measured using quantitative RT?PCR, andimmunohistochemistry. The results showed that the rats in AB METH and ED?binge METH groups had significantly lower theFSH receptor protein expression (strong expression in the stages XII, XIII, XIV, and I of the spermatogenic cycle) comparedwith the control group but had no significant difference in the mRNA expression of FSH and LH receptors. These results mayreflect the adverse effects of METH on FSH functions in testis. |
