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Influence of stabilizers and cryoprotectants on the characteristics offreeze-dried PLGA nanoparticles containing Morus Alba stem extract |
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| รหัสดีโอไอ | |
| Creator | 1. Kanyarat Srihaphon 2. Supaporn Lamlertthon 3. Tasana Pitaksuteepong |
| Title | Influence of stabilizers and cryoprotectants on the characteristics offreeze-dried PLGA nanoparticles containing Morus Alba stem extract |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2564 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 1 |
| Page no. | 72-79 |
| Keyword | Morus alba stem extract, PLGA, nanoparticles, stabilizer, cryoprotectant |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | This study aimed to investigate the effects of stabilizers and cryoprotectants on the characteristics of poly (lactic-coglycolic) acid (PLGA) nanoparticles containing Morus alba stem extract (MSE). The stabilizers used in the preparation of thenanoparticles were polyvinyl alcohol (PVA) and poloxamer 188 at a concentration of 2% w/v. The effects on freeze-drying ofcryoprotectants, including glucose, sucrose, maltose and mannitol at concentrations of 5% and 10% w/v, were investigated. Theresults showed that the presence or the absence as well as the type of stabilizer affected size and charge of the nanoparticles.They also affected the loading capacity and the release of MSE. In freeze-drying, the type of cryoprotectant greatly influencedthe physical stability of the nanoparticles and the chemical stability of encapsulated MSE. The nanoparticles prepared using 2%w/v PVA as the stabilizer and freeze-dried in the presence of 5% sucrose were the optimal carriers of MSE. |
