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Synthesis of thiazolo- and benzothiazolo[3,2-a]pyrimidine derivativesusing onion peel as natural catalyst |
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| รหัสดีโอไอ | |
| Creator | 1. Sian Hui Tan 2. Ban Soon Lim 3. Fu Siong Julius Yong 4. Mahamad Nasir Abdullah 5. Hafiza Mohamed Zuki 6. Seng-Chee Poh 7. Su-Yin Kan 8. Poh Wai Chi |
| Title | Synthesis of thiazolo- and benzothiazolo[3,2-a]pyrimidine derivativesusing onion peel as natural catalyst |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 1 |
| Page no. | 57-64 |
| Keyword | onion peel, thiazolo and benzothiazolo-[3,2-a]pyrimidine, metal-free synthesis, heterocyclic compounds |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | In this work, a facile, metal-free and efficient protocol for the synthesis of thiazolo- and benzothiazolo[3,2-a]pyrimidine-6-carboxylate derivatives using onion peel as catalyst is described. For the first time, the onion peels are used forthe synthesis of thiazolo- and benzothiazolo[3,2-a]pyrimidine-6-carboxylate derivatives. The current protocol has numerousadvantages, including cost-effectiveness, avoiding the use of external acids and bases, and the high porosity of the naturalcatalyst has led to the desired products in good to excellent yields. We anticipate that this environmental friendly catalystpresented here will be of great utility in both research institution and industry. |
