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Improving telmisartan mechanical properties through the formation oftelmisartan and oxalic acid co-crystal by slow evaporation andultrasound assisted co-crystallization from solution methods |
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| รหัสดีโอไอ | |
| Creator | 1. Hestiary Ratih 2. Jessie Sofia Pamudji 3. Fikri Alatas 4. Sundani Nurono Soewandhi |
| Title | Improving telmisartan mechanical properties through the formation oftelmisartan and oxalic acid co-crystal by slow evaporation andultrasound assisted co-crystallization from solution methods |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 1 |
| Page no. | 188-195 |
| Keyword | telmisartan, oxalic acid, co-crystal, slow evaporation, ultrasound assisted co-crystallization from solution |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Telmisartan (TMS) is used for the prevention and treatment of hypertension. However, it has poor mechanicalproperties. The purpose of this research was to improve the mechanical properties of TMS through the formation of co-crystalTMS with oxalic acid (OXA) and to compare the mechanical properties of TMS-OXA 1:1 co-crystal obtained from the differentco-crystallization techniques. Co-crystals were prepared by the slow evaporation (SE) and ultrasound assisted co-crystallizationfrom solution (USSC) methods. The tabletability profiles were plotted between compaction forces in the range of 4.98?29.89 kNvs. tensile strength. The tablet tensile strength of TMS in compaction force >14.98 kN had severe capping or lamination. Incontrast, the tablet tensile strengths of the TMS-OXA SE and USSC co-crystals were higher and could be easily formed intotablets in all of the compaction forces. It can be concluded that the TMS-OXA co-crystals prepared by the SE and USSC methodshave improved mechanical properties of the telmisartan tablet. |
