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Optimized ultrasound-assisted extraction of antioxidant and bioactivecompounds from Ferulago angulata by response surface methodology |
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| รหัสดีโอไอ | |
| Creator | 1. Abdoreza Aghajani 2. Seyed Ali Mortazavi 3. Farideh Tabatabaei Yazdi 4. Masoud Shafafi Zenozian 5. Mohammad Reza Saeidi Asl |
| Title | Optimized ultrasound-assisted extraction of antioxidant and bioactivecompounds from Ferulago angulata by response surface methodology |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 1 |
| Page no. | 8-14 |
| Keyword | antioxidant activity, Ferulago angulata, bioactive compounds, response surface methodology |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | In this study, response surface methodology (RSM) was used to optimize the conditions for the extraction of totalflavonoid content (TFC) and determine the free radical scavenging activity (IC50 value) from Ferulago angulata extract byultrasound bath at constant temperature. The investigated factors in this method were the solvent ratio (ethanol/water at 0 to100%) and extraction time (48 min). Experiments were carried out based on a central composite design. The results showed thatthe extraction conditions had a significant effect on the IC50 value and TFC extraction. The optimal conditions for TFC (0.56mgRE/g) included ethanol content and extraction time and were determined to be 49.49% (v/v) and 7 min and 39 sec,respectively. Furthermore, the IC50 value (1.13 mg/g) was 98.27% (v/v) and 8 min. It was also found that RSM in optimizingextraction conditions, especially in predicting TFC and IC50 values, is an efficient method. These optimized conditions allow therapid and maximum extraction of bioactive compounds from F. angulata. |
