|
Tectona grandis, a potential active ingredient for hair growth promotion |
|---|---|
| รหัสดีโอไอ | |
| Creator | 1. Yunda Fachrunniza 2. Jukkarin Srivilai 3. Vanuchawan Wisuitiprot 4. Wudtichai Wisuitiprot 5. Nungruthai Suphrom 6. Prapapan Temkitthawon 7. Neti Waranuch 8. Kornkanok Ingkaninan |
| Title | Tectona grandis, a potential active ingredient for hair growth promotion |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 6 |
| Page no. | 1352-1359 |
| Keyword | Tectona grandis, 5?-reductase inhibition, anti-testosterone, IL-1? secretion inhibition |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | This study aimed to investigate the biological activities of Tectona grandis L. f. related to hair loss treatment, includingsteroid 5?-reductase (S5AR) inhibition, effect on Human Follicle Dermal Papilla Cells (HFDPCs), anti-testosterone activity,cytotoxicity on macrophage cells and interleukin 1 beta (IL-1?) secretion inhibition. Among the crude extracts, T. grandis leafhexane and ethyl acetate (EtOAc) extracts possessed potent S5AR inhibitions, with IC50 values of 31.39?3.38 ?g/mL and20.92?2.59 ?g/mL, respectively. T. grandis leaf-hexane extract showed lower cytotoxicity on HFDPCs than EtOAc extract.Hexane extract at 25 ?g/mL had similar anti-testosterone activity with a positive control, finasteride, and exhibited 70%inhibition of IL-1? secretion in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Meanwhile, EtOAc extract had loweranti-testosterone activity at 6.25 ?g/mL and exhibited 52% IL-1? secretion inhibition at 1.5 ?g/mL. This discovery suggests T.grandis leaf extracts as a new source of active ingredients for the development of hair care products. |
